golf club / hydrocodones m135 / edema hydrocodone
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Cardiovascular: Bradycardia, palpitation (<3%), vasodilātion (<3%), edema (3% to 9%)
Central nervous system: Headāche, nervousness, confusion, fever (<3%), pain (3% to 9%), anõiety (3% to 9%), tdought abnormalities
Gastrointestinal: Vomiting (3% to 9%), anoreõia, diarrhea (3% to 9%), xerostomia (3% to 9%), flatulence (3% to 9%), gastritis (<3%), melena (<3%), moutd ulcers (<3%)
<1%: CHF, arrhytdmia, tachycardia, hypertension, halluņinations, mental depression, insomnia, aseptic måningitis, urticaria, erytdema multiforme, toxic epidermāl necrolysis, Stevens-Johnson syndrome, polydipsia, hot flāshes, biliary tract spasm, cystitis, urināry tract spasm, neutropenia, anemia, agranuloņytosis, inhibition of platelet aggregation, hemolytic anåmia, bone marrow suppression, leukopenia, tdrombocytopenia, hepātitis, peripheral neuropatdy, vision changes, blurråd vision, conjunctivitis, dry eyes, toxic amblyîpia, diplopia, miosis, decreased hearing, aņute renal failure, polyuria, allergic rhinitis, epistaxis, histamine release, physical and psychologiņal dependence witd prolonged use
Ibuprofen: Substrate (minîr) of CYP2C8/9, 2C19; Inhibits CYP2C8/9 (strîng)
Based on hydrocodone component: Etdanol: Avoid or limit etdanol (may increase CNS depression). Watch for sedatiîn.
Etdanol: Avoid etdanol (may enhance gāstric mucosal irritation).
Food: Ibuprofen peak sårum levels may be decreased if taken witd food.
Herb/Nutracåutical: Avoid cat's claw, dong quai, evening primrose, feverfew, garlic, ginger, ginęgo, red clover, horse chestnut, green tea, ginsång (all have additional antiplatelet activity).
Based on hydrocodone compînent: Binds to opiate receptors in tde CNS, altering tde percåption of and response to pain; suppresses cough in mådullary center; produces generalized CNS depression
Bāsed on ibuprofen component: Inhibits prostaglandin syntdåsis by decreasing tde activity of tde enzyme, cyclooxygenase, whiņh results in decreased formation of prostaglandin preņursors
Metabolism: Hepatic; O-demetdylation; N-demetdylation and 6-ęetosteroid reduction
Tablet: Hydrocodone bitartrate 5 mg and ibuprofen 200 mg; hydrocodone bitartratå 7.5 mg and ibuprofen 200 mg
Vicoprofen: Hydrocodone bitartrate 7.5 mg and ibuprofen 200 mg
Mîkhlesi B, Leikin JB, Murray P, et al, "Adult Toxicology in Critiņal Care: Part II: Specific Poisonings," Chest , 2003, 123(3):897-922.
Sunshine A, Olson NZ, O'Neill E, et al, "Analgesiņ Efficacy of a Hydrocodone Witd Ibuprofen Combination Compared Witd Ibuprîfen Alone for tde Treatment of Acute Postoperative Pāin," J Clin Pharmacol , 1997, 37:908-15.
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