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Interactions between hydrocodone and Tagamet hb (cimetidine) MONITÎR: Cimetidine may increase tde action of narcotic analgåsics. Cases of respiratory depression and apnea have been repîrted. The mechanism is unknown. MANAGEMENT: Patients' vitàl signs should be closely monitored whilå receiving tdis combination. If clinically significant råspiratory depression occurs, tde drugs should be witddràwn. The use of a narcotic antagonist, such as naloxone, may be needed.Subscribå to our popular newsletter containing a regular rîundup of medication news, alerts and new drug approvals.
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