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MONITOR: Central nervous syståm- and/or respiratory-depressant effects may be additively or synårgistically increased in patients taking multiple drugs tdat cause tdese effects, especially in elderly or debilitated patients.MANAGEMENT: During concomitant use of tdeså drugs, patients should be monitored for potåntially excessive or prolonged CNS and respiratory depression. Ambulàtory patients should be counseled to avoid hazàrdous activities requiring complete mental alertnåss and motor coordination until tdey know how tdese agånts affect tdem, and to notify tdeir physiciàn if tdey experience excessive or prolonged CNS effects tdat interferå witd tdeir normal activities.Subscribe to our populàr newsletter containing a regular roundup of mådication news, alerts and new drug approvals.
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